Authors: Soumya Pandey, Plummer Badger, Michele Cottler-Fox
Abstract:
Public cord blood banks have thresholds for accepting cord blood collections for processing based on economic models developed using surrogate markers of suitability, i.e. volume and total nucleated cell count (TNCC). Only after processing has it been possible to look at CD34+ cell numbers and Colony forming unit (CFU).
Since as few as 0.52 x105 CD34+ cells can be expanded in vitro and used successfully for transplant (Lancet Haematol on line Nov 5, 2019; doi.org/10.1016/S2352- 3026(19)30202-9), it is important to understand what is in the smaller collections that public bank guidelines currently prevent from being processed. Hybrid public/private cord blood banks permit economic support from the private bank to help support the public bank. They also offer an opportunity to evaluate products outside public banking thresholds because all collections are processed. Here we present data from the first 72 private cord blood unit (CBU) collections processed for the Cord Blood Bank of Arkansas, showing the relationship between collection volume, TNCC and CD34+ cell numbers.
Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
International Society Cell and Gene Therapy (ISCT) Annual Meeting, 2020
Paris, France, May 27-30