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  1. University of Arkansas for Medical Sciences
  2. Science Reports
  3. Author: Kelly Gardner
  4. Page 2

Kelly Gardner

Examining gender differences in a summer-in-surgery program for second-year medical students.

Authors: Henry T, Kimbrough MK, Thrush CR.

Abstract

Background

National trends continue to show gender disparities among students entering general surgery careers, decreasing rates overall regardless of gender, and predictions for future surgeon shortages.1  Early exposure to surgery career options and mentors are critical for informed decision-making, yet surgical experiences in medical school are typically limited to the third or fourth years.2 Given these challenges, earlier exposure to surgery and understanding barriers and factors influencing students’ career decisions remain topics of research interest.

Goals

Summer-In-Surgery (SIS) is a 4-week elective we created for rising second-year medical students to acquire first-hand experience in general surgery specialties.3-4  The goal of this project is to explore gender differences in SIS participant responses to pre- and post-program surveys evaluating interest in surgical careers and research, comfort level in the operating room (OR), and perceptions of barriers or influencing factors to a career in surgery.

Methods

Between 2016-18, 72 students (56%, n=27 men/44%, n=21 women) have participated in SIS and completed pre (n=70) and post (n=72) evaluation measures to assess surgical career/lifestyle interest levels, influencing factors and barriers. Non-parametric Wilcoxon tests were used to assess gender differences in participants’ survey responses. 

Results

Men and women equally indicated the most influential factor in selecting a surgical career was that it matched with their personality, skills, and interests. Post-SIS responses indicated women perceived their competitiveness and board scores (48%) to be the most significant barrier to pursuing a surgical career, while for men the most prominent barrier was family-work-life balance (43%). Both male and female participants reported significantly increased (p<0.001) comfort in the OR.  Men’s perceptions of surgeon quality of life declined significantly (p<0.05), whereas women’s perceptions improved (though not significantly). Females also reported significant improvements in perceptions of work-life balance (p<0.05) whereas males did not.

Conclusion

The surgical experience provided by SIS showed statistically significant and practical effects on comfort levels in the OR across both genders and identification of students’ perceived barriers to surgical careers. Perceptions of work-life balance and surgeons’ quality of life were significantly improved for women.  Dispelling misperceptions about surgical careers is an important step to improve the surgeon shortage.  

References

  1. Peel JK, Schlachta CM, Alkhamesi NA. A systematic review of the factors affecting choice of surgery as a career. Canadian Journal of Surgery. 2018 Feb;61(1):58.Jolly P, Erikson C, Garrison G. U.S. graduate medical education and physician specialty choice. Acad Medicine, 2013;88(4), 468-474.
  • Cloyd J, Holtzman D, O’Sullivan P, Sammann A, Tendick F, Ascher N. Operating room assist: surgical mentorship and operating room experience for preclerkship medical students. J Surg Educ. 2008 Jul-Aug;65(4):275-82. 
  • Kimbrough M, Thrush CR, Smeds M, Bentley F.  Early Exposure to Surgical Careers:  A Pre-Clinical “Summer in Surgery” Program.  (Innovation Poster). 2016 AAMC Annual Meeting – Learn Serve Lead, Seattle, WA, November 11–15, 2016. 
  • Cobos RJ, Thrush CR, Harris TJ, Smeds MR, Bentley FR, Kimbrough MK. Shaping Medical Student Perceptions: A Pre-Clinical ‘Summer in Surgery’ Program. Journal of The American College of Surgeons. 2017; 225(4, Supplement 2), e160. DOI: https://doi.org/10.1016/j.jamcollsurg.2017.07.960
PosterDownload

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
Association for Surgical Education Annual Conference 2020, April 27-30, Seattle, WA.

Filed Under: Educational Research

Federal Political Contribution Characteristics of Self-Identified Radiation Oncologists in the United States from 2003-2018

Authors: Prabhu AV, Lehrer EJ, Clump DA, Kim T.

Abstract

Background: The health care industry has a diverse group of stakeholders who seek relationships within government to help ensure that certain interests are considered in the legislative process. One of these mechanisms of engagement is enabled through political action committees (PACs), which contribute to federal campaigns and influence candidates and legislation.

Objectives: The purpose of this study was to characterize the federal political contributions of American radiation oncologists (ROs). We hypothesized that ROs have contributed mostly to specialty-focused PACs and increased their political contributions over the last 15 years.

Methods: Institutional review board approval was not needed due to the public nature of this study. Public finance data from the Federal Election Commission (FEC) containing information on individual contributions to a federal candidate or committee was obtained from 2003 through 2018. Data was filtered to only include physicians self-identifying as ROs with individual information associated with the contributor’s state, contribution date, and dollar amount. Contribution recipients were then linked to specific candidates or committees using the FEC’s public campaign finance data, and contribution recipients were manually classified as PAC or a Presidential, Senate, or House candidate or committee. Each individual PAC receiving contributions was noted, such as ASTROPAC (The American Society for Radiation Oncology Political Action Committee), RADPAC (Radiology Political Action Committee), or ACROPAC (American College of Radiation Oncology Political Action Committee). Each recipient candidate and PAC was then classified as Democrat, Republican, or other political party based on FEC designations and overall spending patterns greater than fifty percent to any one political party as detailed by the Center for Responsive Politics (a nonprofit, nonpartisan research group that monitors the flow of money to candidates for political office). Data was analyzed temporally and geographically, in aggregate, and by individual radiation oncologist using summative statistics. Spearman’s rho was used to assess the presence of trends in contributions, where the null- hypothesis was rejected for p<0.05.

Results: From 2003 to 2018, the FEC reported a total of 31,646,000 federal political contributions. Exactly 4,617 federal political contributions were made from 1,021 unique self- identified ROs, totaling $3,350,137. The number of ROs making contributions ranged from 56 in 2005 to 600 in 2016 (mean 289 ± 191.4 ROs yearly), with the mean total annual contribution of $209,384 with a range of $28,952 in 2005 to $543,764 in 2016. The average contribution was $725.61 but amounts ranged considerably (range $1 in 2011, 2012, and 2013 to $35,800 in 2011). Of all RO dollars, 75.4% went to Democrats, 23.8% to Republicans, and 0.8% to others. From 2003-2008, Republicans received the majority of contributions, while Democrats received the majority of contributions during the remaining time frame from 2009-2018. Most RO dollars (81.0%) went to PACs rather than candidates, with the majority of those PAC dollars (50.2%) directed toward ASTROPAC followed by RADPAC (13.6%). ACROPAC received only 0.4% of total PAC dollars. There was a positive annual trend in RO contributions to the House, (=0.58, p<0.02), PACs (=0.85, p<0.0001), Democrats (=0.84, p<0.001), and overall (=0.8, p<0.001).

There was not a significant trend seen in RO contributions over time to Presidential candidates (=0.71, p<0.06) or to the Senate (=0.49, p<0.07).

Conclusions: ROs’ federal political contributions have increased almost 19-fold over the last decade and a half and continues to be an increasing trend. This growth overwhelmingly represents contributions to specialty-focused PACs (ASTROPAC) supporting both Democratic and Republican candidates.

Full PaperDownload

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
102nd Annual American Radium Society Meeting. Scottsdale, AZ. May 16-19, 2020

Filed Under: Other Research

Medical student feedback on a novel curriculum module: Fundamentals of suturing skills (FOSS).

Authors: Gammill S, Phelan K, Bennett T, Thrush C, Golinko M, Hartzell L, Bhavaraju A.

Abstract

BACKGROUND

The ability to suture simple lacerations is a basic expectation for many residents, but recent medical school graduates often feel unprepared to perform this skill.1 Various curricula have been developed by medical schools to facilitate the acquisition of procedural skills such as suturing,2-4 unfortunately, these courses are typically offered only on an elective basis for interested students.5  To address this deficiency amongst incoming interns, many graduate medical education programs have implemented boot camps aimed at teaching basic procedural skills.6-9  To better prepare our medical students for clinical clerkships and beyond, we implemented a mandatory progressive, longitudinal suturing curriculum and present survey results from the initial cohort of students.

METHODS

All students are provided online video resources and suturing materials for independent practice, followed by six hours of hands-on instruction starting on their own gross-laboratory cadavers ,during divided sessions throughout the M1 and M2 years covering key suturing skills (ex. correct instrument position, instrument and hand knot tying, various suturing techniques). With each session, students are checked off on what they have learned the previous session and then focus on practicing the next set of skills. Finally, a 2-hour refresher session is provided immediately prior to starting M3 clinical clerkships. FOSS sessions are led by clinical faculty, residents, and peer tutors. M1 students completed course evaluation surveys before (n=167) and after (n=148) the first FOSS session to assess pre-course suturing experience, comfort level with previously stated skills, and impressions about the overall course design. 

RESULTS

Prior to the course, just over one-third (37%) had no suturing exposure or direct suturing experience. Of the 63% of students with prior exposure, less than 5% had any direct suturing experience. There was a statistically significant improvement in students’ ratings of their comfort with proper instrument position, performing simple interrupted sutures, and performing instrument ties (p<0.0001). 83% of students rated the gross lab sessions as excellent. The majority of students found the FOSS resources very helpful: materials and self-study guides (91%); clinical faculty (99%); session time (99%).

CONCLUSIONS

Based on positive responses and improved comfort level with basic suturing skills, the program appears to be a worthwhile use of both faculty resources and students’ time. Students were also exposed to suturing much earlier than otherwise expected during their medical education. Future work will examine the potential impact on students’ performance during clinical rotations.

References

  1. Fargo MV, Edwards JA, Roth BJ, Short MW. Using a simulated surgical skills station to assess laceration management by surgical and nonsurgical residents. J Grad Med Educ. 2011 Sep;3(3):326-31.
  2. Lemke M, Lia H, Gabinet-Equihua A, et al. Optimizing resource utilization during proficiency-based training of suturing skills in medical students: a randomized controlled trial of faculty-led, peer tutor-led, and holography-augmented methods of teaching. Surgical endoscopy. 2019 Jul 8:1-0.
  3. Manning E, Mishall P, Weidmann M, et al. Early and prolonged opportunities to practice suturing increases medical student comfort with suturing during clerkships: Suturing during cadaver dissection. American association for anatomy. 2018 Mar;11(6)
  4. Miller S, Shipper E, Hasty B, et al. Introductory Surgical Skills Course: Technical Training and Preparation for the Surgical Environment. MedEdPORTAL. 2018;14:10775. Published 2018 Nov 28. doi:10.15766/mep_2374-8265.10775
  5. Antonoff M, Green C, D’Cunha J. Operative and technical skills for the senior medical student entering surgery. MedEdPORTAL. 2013;9:9470.
  6. American Academy of Family Physicians. Recommended curriculum guidelines for family medicine residents. Care of the Surgical Patient. 2008. Obtained from:  https://www.aafp.org/dam/AAFP/documents/medical_education_residency/program_directors/Reprint259_Surgical.pdf
  7. Dean KM, DeMason CE, Choi SS, Malloy KM, Malekzadeh S. Otolaryngology boot camps: Current landscape and future directions. Laryngoscope. 2019; 9999:1–6. [Epub ahead of print]
  8. Ataya R, Dasgupta R, Blanda R, Moftakhar Y, Hughes PG, Ahmed R. Emergency medicine residency boot Camp curriculum: a pilot study. West J Emerg Med. 2015 Mar;16(2):356-61.
  9. Promes SB, Chudgar SM, Grochowski CO, Shayne P, Isenhour J, Glickman SW, Cairns CB. Gaps in procedural experience and competency in medical school graduates. Acad Emerg Med. 2009 Dec;16 Suppl 2:S58-62.
SGEA-Poster_Flow-Chart-Version_v3Download

Conference/Symposium/Course name where the work was supposed to be presented:
AAMC Southern Group on Educational Affairs (SGEA) Annual Meeting

Filed Under: Educational Research

Novel Salinomycin Analogs Show Improved Selectivity Towards Breast Cancer Stem Cells

Authors: Alicja Urbaniak, Megan R. Reed, Michał Antoszczak, Michał Sulik, Adam Huczyński, Robert L. Eoff, Melanie C. MacNicol, Angus M. MacNicol, Timothy C. Chambers

Abstract

Breast cancer tumor metastasis is the leading cause of mortality among women. Cancer stem cells (CSCs) are the tumor-initiating cells which drive initiation, progression, metastasis, and tumor reoccurrence. Their resistance to conventional chemo- and radiotherapies and their ability to survive such treatment enables tumor reestablishment. Thus, therapeutic strategies targeting CSCs hold great potential for novel advances in cancer treatment. Salinomycin (SAL) is a naturally occurring polyether ionophore antibiotic with anti-cancer activity towards various types of tumor cells, but its toxicity towards normal cells limits broad application. A library of 21 novel SAL analogs was screened to identify compounds with improved selectivity especially against breast cancer stem cells. SAL analogs were either single modified with ester or amide in the C1 position or double-modified C20-oxo derivatives. Eight single- and two double-modified derivatives were more potent (IC50 range of 1.13 ± 0.19 to 3.93 ± 0.39 μM) towards the breast cancer cell line MDA- MB-231 compared to SAL (IC50 of 5.81 ± 1.50). These derivatives induced DNA fragmentation suggestive of apoptotic cell death. Further, most of these derivatives had improved selectivity toward MDA-MB-231 cells compared to SAL when also tested against normal breast epithelial MCF10A cells. In addition, a butyl ester derivative of SAL, chosen based on increased potency and selectivity versus SAL, significantly reduced the colony-forming efficiency of MDA-MB-231 cells in association with selective loss of the CD44+/CD24-/low stem-cell-like subpopulation. Select derivatives were next screened against the NCI-60 Human Tumor Cell Line Panel. A double- modified analog of C20-oxo-SAL with hydroxamic acid was found to be more potent than SAL towards all 6 breast cancer cell lines in the panel as well as other tumor types especially leukemia. Studies are underway to test the analogs in three dimensional culture using breast cancer organoids derived from both cell lines and patients. The present findings highlight the therapeutic potential of SAL analogs towards breast cancer and breast cancer stem cells and support further research and clinical development of these compounds.

Funding: The present study was funded by grants (to AM and TCC) from the Arkansas Breast Cancer Research Program.
Testing was performed by the Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, http://dtp.cancer.gov.

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
Experimental Biology 2020, April 4-7 2020, San Diego

Filed Under: Basic Sciences

Pediatric Flexor Tendon Injuries

Author: Theresa O. Wyrick, M.D.

Pediatric-Flexor-Tendon-InjuriesDownload

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
Philadelphia Hand Symposium
Philadelphia, PA
Friday March 13, 2020

Filed Under: Clinical Sciences

Effect of shake-fire delay on the amount of delivered dose from a pMDI albuterol HFA

Authors: Rasha Qaqish, M.D., and Ariel Berlinski, M.D.

Poster

PDF-Poster-shake-delayDownload

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
– The ATS International Conference Committee presentation at the 2020 ATS International Conference, scheduled for May 15-20 in Philadelphia
– 43rd European Cystic Fibrosis Conference

Filed Under: Other Research

Positive Psychiatry and Positive Psychotherapy Tools to Work and Age Well

Authors: Messias E, Flynn V, Peseschkian H, Jeste D, Christ C.

Abstract

Most adults spend more time at work than anywhere else. Given the fact that the majority of adult life is spent working, workplace wellbeing becomes increasingly important for overall wellbeing. In contrast to wellbeing, professional burnout is a syndrome of emotional exhaustion, depersonalization or cynicism, and low sense of personal accomplishment in response to chronic occupational stressors. Professional burnout affects one’s ability to successfully navigate the unique challenges at various stages of professional development, especially those during periods of role transition from learner to apprentice to early career professional. The consequences of burnout include depression, coping with alcohol or drug use, and broken relationships and professional errors, decrease in satisfaction, and intent to leave one’s job. Unfortunately, rates of professional burnout in human services professions have increased over the last decade. The unique professional challenges and opportunities can be viewed through a developmental lens, similar to Erikson’s psychosocial development model, and traversed by enhancement of various character strengths and virtues. An emphasis on positive psychosocial factors and enhancement of various character strengths and virtues may counter the negative response to these challenges. With the help of a professional coach or mentor, professional development can be navigated and personal, professional, and leadership development successfully guided.

Positive Professional Development – APA 2020 PresentationDownload

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
APA Annual Conference, Tuesday, April 28, 2020

Filed Under: Clinical Sciences

Assessment of Technology Use as a Valuable Diagnostic and Therapeutic Tool

Abstract

Authors
Zeynep Ozinci, M.D. (chair), Musa Yilanli, M.D., Caroline Nardi, M.D., Srinivasa Gokarakonda, Nihit Kumar, MBBS

Technology Use (TU) is prevalent especially in children and teenagers, and there is a growing need for better understanding and assessing its impact on patients’ lives and daily functioning. An increasing body of literature reveals the direct and indirect impact of TU, and addressing clinical concerns regarding TU associated with academic difficulties, anxiety, depression, sleep problems, behavior addictions and deficits in overall functioning. To maintain and improve the quality of mental health care, there is a need to explore the TU of our patients and its associations with psychiatric disorders, and also develop clinical skills on how to effectively ask the pertinent questions (social media use, browsing, gaming as well as the content, frequency, and duration of use per day, late night or early morning use, etc.) The application of new interview practices in clinical psychiatry is indeed necessary and has the potential to help with reduction in symptoms and increase in academic performance, social skills, empathy, compassion, resilience and well being.

Being familiar with TU in the digital age and practical guidelines will increase a clinician’s overall knowledge, confidence, and clinical skill set in conducting effective interviews with the patients to help them overcome the negative consequences and engage in healthier technology use; while maintaining a successful therapeutic alliance.

During our session, we will summarize the current evidence base on the effects of TU on behavior, attention, cognitive skills, academic performance, impulsivity, mood, and sleep. Participants will gain a better understanding of the impact of TU in patients’ lives and the importance of implementing techniques into practice to better evaluate their social skills and development as well as their interests, strengths, and challenges.

We will provide information on practical interviewing skills and assessment techniques to further obtain information about the patients’ use of technology, to observe their thought process, decision- making, impulsivity, and temperament among other aspects of the clinical presentation; at the same time build rapport and establish a therapeutic alliance during the interview.

The audience will also become familiar with popular videogames and social media sites being used by youth, understand their potential positive and negative impact, learn how to use this knowledge to help children and families, and feel comfortable integrating new interview skills into their practices. It will help the participants address the needs of the patients in order to provide comprehensive care to the children and adolescents and improve their wellbeing through a review of scientific findings and practical guidance. Participants will then be given a chance to contribute to the topic and discuss possible interventions during video clip presentations. And at the end of the session, the audience will be provided with reliable resources to further their learning.

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
2020 Annual Meeting of the American Psychiatric Association, April 25-29, 2020, Pennsylvania Convention Center, Philadelphia, PA

Filed Under: Clinical Sciences

Analysis of Partnerships for Colorectal Cancer Screening

Abstract

Authors
Margaret Woods, B.A.; Dina Jones, Ph.D., M.P.H.; Nicole McGehee, M.Ed.; Karen Crowell, M.D.; Pebbles Fagan, Ph.D., M.P.H.; Ronda Henry-Tillman, M.D., FACS

Purpose

Colorectal cancer (CRC) screening is increasing in Arkansas (AR), but screening rates remain below the national average and incidence and mortality rates remain higher than the national average. To address these disparities, the AR Colorectal Cancer Screening and Prevention Program (CCSP) disseminated fecal immunochemical tests (FITs) to individuals in all five public health regions through partnerships (e.g. community events, primary care visits, community partners, gastroenterologists, and federal qualified health centers (FQHCs)). The purpose of this study was to assess differences in the FIT return rate by partnership type, region, and red county status.

Design Methods

The CCSP program data from 2016 to 2019 were analyzed. Univariate and bivariate (t tests, ANOVA) were conducted in SAS 9.4 to examine the relationship between the outcome FIT return rate (number of FITs received/number of patient referrals received) and the variables partnership type, region, and red county status (a county with a life expectancy ≤74.0 years). 

Results

From 2016 to 2019, the CCSP collaborated with 72 partners with an average FIT return rate of 57.4%. The FIT return rate significantly differed by partnership type (F=7.41, 4 df, p<.0001) with FQHCs having the highest average return rate (Mean: 72.2, SD:19.2) and gastroenterologists having the lowest (Mean: 27.2, SD:38.4). Partners in Central AR had a significantly lower FIT return rate (50.1 v 65.0) as compared to organizations outside of Central AR (t=2.19, 69 df, p=.03). No differences were observed in the average FIT return rate by red county status.

Discussion/Conclusion

Our data suggest that FQHCs may be a highly valuable partner to work with to increase CRC screening in AR. Studies are needed to determine the reasons for lower rates of FIT return among other health care provider offices.

Grant Support

The Colorectal Cancer Screening Program is funded by appropriations from the State of Arkansas, Arkansas Department of Health. Dr. Jones is supported by a grant from the National Institute on Drug Abuse (T32 DA022981, PI: C, Kilts).


Community Support:
Arkansas Counties and Federal Qualified Health Centers

Conference/Symposium/Course name, dates and location where the work was supposed to be presented:
Xavier University of Louisiana 13th Health Disparities Conference
March 25-27, 2020, New Orleans, LA

Filed Under: Other Research

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